A recent clinical report from the ASPCA Poison Control Center has shown that dogs appear to develop severe liver failure and sudden decreases in blood sugar levels after ingesting foods containing the sweetener, Xylitol. Clinical signs of liver injury include depression, vomiting, icterus, and coagulopathy; other findings include hyperbilirubinemia, thrombocytopenia, and hyperphosphatemia. It can be produced by hydrolysis from different plant sources having polysaccharides. Lead Poisoning in Dogs and Cats. Chocolate Toxicity Calculator Chocolate toxicosis may result in potentially life-threatening cardiac arrhythmias and CNS dysfunction. Test animals Species: rabbit Strain: other: Yellow-Silver Details on test animals and environmental conditions: TEST ANIMALS - Age at study initiation: 3-4 months - Weight at study initiation: 2.7-3.0 kg - Housing: housed in individual stainless steel cages - Diet (e.g. Pet Poison Helpline has a large data base cataloging the specific xylitol content for many products, and the list is growing every day. Xylitol toxicity can occur after just 30 minutes. Do you really want to try and calculate your dog’s weight vs how much xylitol you believe he or she may have eaten? The compound doesn’t affect glucose levels in people, but when ingested by dogs it can cause a dangerous surge of insulin. Particularly when we know that xylitol toxicity does have the potential to be toxic in dogs? Top 10 pet poison lists, seasonal and holiday poisons. Xylitol not first sugar alcohol. Over the last few years its popularity has increased thus causing increased risk of exposure. Plants. Xylitol is a low-calorie, crystalline sweetener which is naturally present in fibrous plant foods and hardwood trees. Chocolate Toxicity Signs in Dogs. It is postulated that hyperinsulinemia is induced by the liver converting xylitol into metabolites that interfere with normal pentose phosphate pathways affecting regulation of insulin synthesis and release. Dogs are at risk for hypoglycemia at doses >100 mg/kg, while the risk for hepatic damage begins at doses >500 mg/kg. Hypoglycemia has been reported in dogs ingesting > 0.1mg/kg of body weight of xylitol, while dogs ingesting > 0.5mg xylitol/kg of body weight are at risk for development of liver toxicity. Xylitol: 2.4 calories per gram; Store-bought xylitol appears as a white, crystalline powder. There have been reports of some dogs eating only a small handful of grapes before then showing signs of poisoning. Xylitol Poisoning Treatment. Xylitol Toxicity Calculations • Example: 20kg dog ingesting 14 pieces of gum with xylitol NOT listed as first sugar alcohol –14 pcs x 0.3g = 4.2g/20kg = 0.21g/kg TOXIC/Hypoglycemia –14 pcs x 75mg = 1.05g/20kg = 0.052g/kg SUB-TOXIC Xylitol Calculation Misconceptions Neitherof these gums Contain 0.3g xylitol per piece! Expandable Foaming Glues like Gorilla Glue Cause Obstructions in Pets . Xylitol. Toxicity Calculator (calculator can take a few seconds to load) Individual Sensitivity. Xylitol is a sugar substitute that is commonly used in sugar-free gum and candy, nicotine gum, toothpaste, baked goods, and chewable vitamins. A crude calculation based on the label may be of help but this is unreliable at best. This especially applies when it comes to liver toxicity. Top 10 poisonous plants . Gum is different. (*Note that the amount of xylitol in gum is highly variable, and not always noted on the packaging. Dogs are extremely sensitive and even small quantities can cause toxicity. Dogs with xylitol toxicity may have bleeding disorders; coagulation profiles and fibrinogen testing will be done to confirm these types of disorders. This is enough time for symptoms of poisoning to show, including vomiting and hypoglycemia. Because toxicity can be expected up to 72 hours after xylitol ingestion, liver values in dogs should be checked up to 3 days or longer if elevated or increasing at any point. Treatment for Xylitol Poisoning in Dogs. xylitol toxicity calculator. Chocolate contains a chemical called theobromine, which is poisonous to dogs. Common Household Items can Poison Pets. Oral xylitol has a wide margin of safety in most species. Hyperphosphatemia is considered a poor prognostic indicator, because it was present in 4 of 5 dogs that died of liver failure after xylitol ingestion (phosphorus was not measured in the fifth dog). Wismer said some xylitol used in candies and mints is in a powder that is absorbed quickly in the system, causing signs of illness in 30 minutes. Xylitol is an artificial sweetener that is found in many sugar-free products such as chewing gum. Usually, this can occur in less than 36 hours in dogs that are otherwise healthy and young. Xylitol is a common sugar substitute that can be toxic to dogs in even small amounts and it can be fatal. In dogs, doses > 0.1 g/kg are considered toxic and result in profound, sudden problems. The Top 10 most common toxins owners call for. Read below for information on our efforts to change labeling standards and see what you can do to help.) Due to the rapid absorption of xylitol, common poisoning treatments are not effective. Pathogenesis: Theobromine and caffeine are readily absorbed from the GI tract and widely distributed throughout the body. 50 grams of sugar equals 50 grams of xylitol, and 85 grams of sugar means 85 grams of xylitol. 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